Reg3d regenerating islet-derived 3 delta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Reg3dprovided by MGI
Official Full Name: regenerating islet-derived 3 deltaprovided by MGI
Primary source: MGI:MGI:1353426
See related: Ensembl:ENSMUSG00000068341 AllianceGenome:MGI:1353426
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: INGAP; Ingaprp
Summary: Predicted to enable several functions, including identical protein binding activity; oligosaccharide binding activity; and peptidoglycan binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell wall disruption in other organism; and response to peptide hormone. Predicted to be active in extracellular space. Orthologous to human REG3A (regenerating family member 3 alpha) and REG3G (regenerating family member 3 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in small intestine adult (RPKM 13.5), spleen adult (RPKM 3.6) and 2 other tissues See more
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Genomic context

Location:: 6 C3; 6 34.76 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (78352857..78355848, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (78375874..78378865, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunoreactivity to INGAP localized to the pancreatic endocrine cells in mouse. INGAP and/or related group 3 Reg proteins have a conserved expression in the pancreatic islet.
Title: Pancreatic islet immunoreactivity to the Reg protein INGAP.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: regenerating islet-derived 3 delta

Names: Reg III delta; islet neogenesis associated protein-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161741.1 → NP_001155213.1 regenerating islet-derived 3 delta isoform 2 precursor

See identical proteins and their annotated locations for NP_001155213.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AB035204, AI594831, BM055959

Consensus CDS

CCDS51815.1

UniProtKB/TrEMBL

G3UWG6

Related

ENSMUSP00000132220.2, ENSMUST00000167492.4

Conserved Domains (1) summary

cl02432
Location:40 → 127

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
NM_013893.2 → NP_038921.2 regenerating islet-derived 3 delta isoform 1 precursor

See identical proteins and their annotated locations for NP_038921.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB035204, AI594831

Consensus CDS

CCDS20254.1

UniProtKB/TrEMBL

Q9JMH1, Q9QUS9

Related

ENSMUSP00000087096.2, ENSMUST00000089667.8

Conserved Domains (1) summary

cl02432
Location:40 → 173

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain